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Safety is unknownand potentially problematic

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Educational level and health literacy affect how women describe their symptoms and advocate for appropriate care

However, a recent randomized, double-blind, controlled study, performed in 60 healthy postmenopausal women conclude that while there was a E2 decrease when giving anastrozole (an inhibitor of aromatase activity), but no changes in E2 levels were observed when fulvestrant (a selective estrogen receptor- antagonist) was administered