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Christensen MB, Lund A, Calanna S et al (2018) Glucose-dependent insulinotropic polypeptide (GIP) inhibits bone resorption independently of insulin and glycemia

Activating an oncogenic pathway in healthy patients is not a comfortable position for a drug development program

Less cooperative

59,60 Folate-mediated one-carbon metabolism Folate-mediated one-carbon metabolism has been long recognized and attributed to its function of producing one-carbon units for nucleic acid and methionine synthesis, another crucial function of this pathway is generating reducing power NADPH

Depletion of the brain antioxidant glutathione (GSH) may be important in OS-mediated neurodegeneration, though studies of post-mortem brain GSH changes in AD have been inconclusive