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Massey 2003)

The pathophysiology of bacterial-endotoxin mediated tissue damage may involve the interplay of reduced host carnitine levels and pathogenic requirement of carnitine for growth and survival in the host [95]

However, despite the many advances in CAD treatment, the disease is invariably associated with many limitations, most significantly the comorbid conditions that complicate treatment protocols and patients quality of life

Given the disease burden of neuropathic pain, many patients turn to over-the-counter supplements

[64] One example of a specific genetic variation linking carnitine deficiency and autism is the TMLHE gene mutation