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Both compounds are classified in category (Cat) 1 of the Carcinogenic Potency Categorization Approach (CPCA), which assigns NAs to one of five categories, ranging from highest (Cat 1) to lowest carcinogenic potency (Cat 5), based on their structural features

Volatile agents reduce presynaptic glutamate release probability in hippocampal synapses and postsynaptically inhibit N -Methyl-d-Aspartate receptor currents (32)

As an antioxidative and anti-inammatory agent, vitamin B12 was observed to lessen oxidative damage and neuroinammation, hence preventing epileptogenesis