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The consequent intracellular calcium overload, driven by the Na/Ca exchanger, further disrupts cellular homeostasis [1]

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SCFAs like butyrate, which are generated through probiotic fermentation of dietary fiber, inhibit HDACs, leading to epigenetic silencing of pro-inflammatory cytokines (e.g., IL-1, TNF-) by downregulating NF-B and upregulating IL-10 by activating STAT3 (98, 102, 103)