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doi: 10.1016/j.biochi.2022.03.013

Chromosomally encoded gyrase inhibitor GyrI protects Escherichia coli against DNA-damaging agents

SIRT1 targets over 100 different proteins involved in metabolism, stress responses, and longevity pathways, including the tumor suppressor p53, the transcriptional coactivator PGC-1, and the DNA repair protein Ku70. Through deacetylation of PGC-1, SIRT1 promotes mitochondrial biogenesis and oxidative metabolism, while deacetylation of p53 reduces apoptotic responses to mild stress, promoting cellular survival and longevity

These splicing modifications can Shift the reading frame, allowing production of partially functional proteins, as demonstrated in treatments for DMD

The association of food consumption and nutrient intake with endometriosis risk in Iranian women: a case-control study
