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When oxidized, the primary structure of Hb is altered by the establishment of disulfide cross-links between globin chains that make the molecule unstable, leading to the formation of Heinz bodies and, eventually, to a premature RBC removal [11]

26,174 Conclusions and perspectives Over the past 5 years, we have witnessed an outbreak of ferroptosis research in biomedicine, which has resulted in the publication of over 1000 papers

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