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This is particularly relevant for oral administration, which is subject to intrinsic factor saturation and receptor limitations in the ileum ( Moreover, our results highlight the essential role of vitamin B12 in homocysteine metabolism, as supplementation was associated with a significant reduction in serum homocysteine levelsan important biomarker associated with cardiovascular and neurodegenerative diseases

doi: 10.1016/J.SOARD.2013.12.014

Safety and side effects A proper daily dosage of a vitamin B12 supplement is very safe

Unlike the synthetic cyanocobalamin found in many cheap supplements, methylcobalamin is already in a form the body can use for cellular metabolism, DNA repair, and energy production

This can make acne appear more persistent or harder to manage