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In addition, microglial plasticity to adopt an anti-inflammatory or pro-inflammatory phenotype is also altered as a consequence of age ( Several factors contribute to the acquisition by retinal microglia of a pro-inflammatory phenotype during ageing, including altered metabolism and reduced immunomodulatory signals from retinal neurons, such as the CX3CL1-CX3CR1 and CD200-CD200R signaling pathways, resulting in increased microglial activation ( As with microglial cells, astrocyte activation is also one of the hallmarks of physiological ageing (Nichols et al., 1993