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Mechanisms underlying the action of TG include both genomic (via nuclear receptors) and non-genomic (membrane) effects

Our further experiments confirmed a daf-16 -dependent activation of cyp-35B and hsp-16.2 and demonstrated that in the absence of LROs, DAF-16::GFP exhibited increased and more persistent nuclear translocation, suggesting that yet unknown LRO-specific signals are indispensable for DAF-16 to activate the expression of its targets in response to BA

Circulation 143 , e254e743 (2021)

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