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Lipid peroxidation leads to the formation of lipid hydroperoxides, which can disrupt membrane fluidity and impair the functionality of membrane proteins

Therefore, we hypothesized that the excessive expression of GJs post-APAP exposure in hepsin / mice could be a key factor contributing to the increased severity of liver damage observed following APAP administration

It is evident that dysregulation of the Nrf2 pathway and regulation of the inflammatory response and ferroptosis play key roles in the pathogenesis of several lung diseases, making Nrf2 a potential therapeutic target

Variants in genes such as FTO (rs9939609), MC4R (rs17782313), and other lipid-metabolism loci may influence how efficiently your body mobilizes fat and responds to metabolic interventions