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Authors Note

Widely recognized for its therapeutic properties, Curcumin is extensively utilized for its antioxidant, anti-inflammatory, wound-healing, and anticancer potential, making it a promising agent for inhibiting cancer initiation and progression ( Despite outstanding therapeutic applications, curcumin faces significant limitations, including poor solubility, limited absorption, restricted tissue distribution, and rapid metabolism

Kietzmann, T

Should RISE find one or more interventions to be promising, it is likely that a larger clinical trial will follow

Nevertheless, ROS may leak in the intermediate steps of the reaction, known as reaction decoupling, which leads to elevated ROS levels and incomplete substrate oxidation [48]