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ber drei pharmakologische Hauptmechanismen VEGF-Aktivierung mit Angiogenese-Frderung (Neubildung von Blutgefen in geschdigtem Gewebe), Stickstoffmonoxid-Signalweg-Aktivierung fr Mikrozirkulation und anti-entzndliche Wirkung, sowie Wachstumsfaktor-Modulation (EGR-1, FAK) fr Zell-Migration und Geweberegeneration

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Sixth, there are clinically important limitations associated with this review, including consistent definition of outcome measures across studies, a well-established MCID for the MMSE score, lack of consideration of drug doses due to inconsistent reporting and data retrieval bias that we were unable to overcome (15% of the studies shared their IPD)