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Toxic prediction of pyrrolizidine alkaloids and structure-dependent induction of apoptosis in HepaRG cells

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These proteins, although not annotated in UniProt Knowledgebase as involved in reproduction, have been previously reported in the literature as involved in preventing spontaneous acrosome reaction ( Importantly, we reported in the panel of down-regulated proteins 9 seminal plasma proteins (Semenogelin-1 (SEMG1), Semenogelin-2 (SEMG2), myeloperoxidase (MPO), MSMB, SERPINA5, Prolactin-inducible protein (PIP), Prostate-specific antigen (KLK3), PSAP and Zinc-alpha-2-glycoprotein (AZGP1))
