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References: Schnyder G, et al

Proc Natl Acad Sci USA 98: 1300-1305

Furthermore, NRF2 controls genes encoding enzymes governing different metabolic pathways, such as lipogenesis and lipid degradation, lipid transport and uptake, enzymes of the pentose phosphate pathway, and some enzymes of glycogen metabolism, like glycogen branching enzyme (GBE) and phosphorylase b kinase subunit A1 (PHKA1), recently linked to NRF2 signalling in the muscle [165] (Fig

This in turn enables the activation of defense signaling proteins and transcription factors which helps to establish innate immune memory (Lindermayr and Yildirim, 2025)