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These TEAEs are similar to those previously reported in the phase 2 ENDEAVOR study [6], which investigated the safety and efficacy of dersimelagon in patients with EPP and XLP, with the most common TEAEs being nausea (27.9%), ephelides (23.5%), and skin hyperpigmentation (20.6%)

[DOI] [PubMed] [Google Scholar] 30.Gennaro R., Barletta D., Paulis G

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Functional studies indicate that glutathione peroxidase activity saturates at 7090 g/L serum selenium, further explaining why supplementation beyond this threshold may not enhance antioxidant capacity ( 5.4 Practical considerations In selenium-replete populations, large trials (e.g., SELECT) found no reduction in cardiovascular events with 200 g/day of selenomethionine and even observed a potential rise in type 2 diabetes incidence (Zhang et al., 2017)

Int J Biol Macromol 195:565588