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Sleep is supposed to be regulated by two types of mechanisms

Increased mitochondrial arginine metabolism supports bioenergetics in asthma

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The incidence of dementia among DS patients is 10% in the age range 3550 yr and 55% in the age range 5060 yr and becomes 75% above the age of 60 yr, but AD neuropathology is present in virtually all adults with DS older than 40 yr (460)
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