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Description
Available treatments for acne have various challenges because it injures the mechanical barrier of the skin, thereby drying it out and stimulating it

doi: 10.1172/JCI118499 66

This response is characterised by upregulation of several cytoprotective and detoxification genes, including ferritin, GSH- S -reductase (GSR), GST, GCLM, and GCLC, phase-I drug oxidation enzyme NAD(P)H:quinone oxidoreductase 1 (NQO1), MRP, and heme oxygenase-1 (HO-1) [78, 79]

Boosting GPX4 activity, therefore, holds promise as a precise therapeutic strategy to delay or even reverse AMD progression

USA 105 , 20582063 (2008)
