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Cut corners on any of them, and you're just guessing

Herrmann W et al., Osteoporos Int 2009 B12, homocysteine, and bone health

The double-blind placebo control in this study eliminates this as an explanation for the results

Why Does My Body React This Way to B12 Injections

Additionally, individuals with digestive conditions like Crohns or Celiac disease often struggle with nutrient absorption, making Vitamin B-12 injections a more effective solution