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The propellants used were formerly chlorofluorocarbons (CFCs), but due to concerns about their destructive effect on the ozone layer, these started to be replaced with hydrofluoroalkanes (HFAs) in the 1990s (though they were not completely phased out from manufacturing until 2012)*

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Furthermore, protease-activated receptor 2 (PAR2) signaling in melanocytes amplifies oxidative and inflammatory responses through the Akt/NF-B axis, elevating cytokine production and reducing antioxidant defenses, based on CAT and SOD activity, exacerbating skin inflammation 126