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In addition, the vaccine improved the physical activity of middle-aged mice (50 weeks old) and extended the median lifespan of ZMPSTE24 KO mouse (model of progeria), an extreme model of accelerated aging 62

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This carefully orchestrated timing mechanism, observable both in vitro and in vivo, ensures that the cortex is organized in a structured manner, with older neurons establishing foundational deep layers and newer neurons refining the upper layers