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identified three CRGs (ENO3, SLC16A1 and LEPR), and Li et al

Neuropharmacology 75 , 407415 (2013)

The DAS28 score ranges from 0 to 9.4, with higher scores indicating greater disease activity

Furthermore, indirect data suggest that barrier defect might precede the onset of disease (316) and up to 40% of first-degree relatives of patients with Crohn's disease demonstrate an altered small intestinal permeability (317)

The AAD recommends aiming for a total goal of cumulative dose of 120 to 150 mg per kg over the entire treatment course, but some evidence suggests higher doses may decrease the risk of relapse without a clear increase in risk 11 12