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In addition, the K-Ras, B-Raf, and c-Myc oncogenes can transcriptionally induce Nrf2, and miRNAs can target NFE2L2 or the 3 UTR of KEAP1 mRNA [69]

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Those with MTHFR gene mutations lack the enzyme required to activate folic acid, which can result in a buildup of unmetabolized folic acid (UMFA)
