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At $795 per cycle, the stack addresses both local tissue repair and systemic inflammation simultaneously, and the clinical rationale is straightforward: the two peptides work through non-overlapping mechanisms that produce additive effects when both are present

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To complement the Jadad score, the Cochrane Risk of Bias Tool (RoB 2) (Sterne et al., 2019) was also used for RCTs to provide a domain-based qualitative evaluation, assessing risks related to selection, performance, detection, attrition, and reporting