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Other clinically important agents, however, display limited ISF penetration due to their molecular size, hydrophobicity, or strong protein binding

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Hexarelin: Mechanism and evidence base Hexarelin (examorelin, CAS 140703-51-1), a synthetic hexapeptide (CHNO, MW 887 g/mol), is the most potent GHS-R1a agonist in the GHRP class by comparative GH-stimulating assay, but is distinguished by a prominent cortisol and ACTH co-stimulation and a set of GHS-R1a-independent cardiac binding data that has generated a distinct line of cardioprotective research

Biochem Biophysical Res Commun 58:579585 Asada K, Urano M, Takahashi M (1973) Subcellular location of superoxide dismutase in spinach leaves and preparation and properties of crystalline spinach superoxide dismutase

Neuroimaging studies corroborate these findings