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SCFA: short-chain fatty acids

However, under oxidative stress, Bach1 dissociates from the HO-1 promoter, and stress signals induce the dissociation of Nrf2 from Kelch-like ECH-associated protein 1 (Keap1), which then binds to AREs and initiates the downstream expression of oxidative stress-resistant HO-1 to prevent ROS-induced cellular damage and maintain the organisms antioxidant response (Zhang et al., 2019)

Origin of cadmium-induced reactive oxygen species production: Mitochondrial electron transfer versus plasma membrane NADPH oxidase

International journal of molecular sciences , 24 (1), 223

To illustrate, polymeric scaffolds with low crosslinking densities have high permeability which promotes the rapid release of the drug while high crosslinking density polymers lead to a sustained release