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Fatigue often results from mitochondrial dysfunction, hormonal imbalances, chronic inflammation, and metabolic dysfunction
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The ratio of reduced to oxidized glutathione (GSH/GSSG) redox couple is an indicator of the cellular redox status 5,25
Overall, we showed that ADA2-deficient cells exhibit an impairment in the pentose phosphate pathway likely leading to an impairment of the oxidative stress response that is improved by HSCT
