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proved that most ovarian cancer cell lines express CPT1A highly and that its inactivation decreased cellular ATP levels, inducing cell cycle arrest at G0/G1 33

Glycerol phenylbutyrate (GPB) is a medication approved by the Food and Drug Administration in 2013 for the treatment of patients with urea cycle disorders or innate metabolism errors that manifest as hyperammonemia, whose effect was emulated in the cirrhotic population.49 GPB is hydrolyzed by pancreatic lipases for producing glycerol and 3 molecules of phenylbutyric acid

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At the 1.5 g /day dose of GPLC, improvements in PP and MP were observed compared to baseline values

[DOI] [PMC free article] [PubMed] [Google Scholar] 169.Jankovic J., Tan E.K