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The potential protective role of VitB12 and its underlying mechanism were investigated by researchers in SH-SY5Y cells, which were overexpressing TDP-43 [134], and it was observed that mitochondrial toxicity induced by TDP-43 in SH-SY5Y cells led to disruptions in the mitochondrial membrane potential, intracellular calcium balance, reduced oxygen consumption, and decreased ATP production

In renal clear cell carcinoma, disulfiram demonstrated potent antitumor activity by inhibiting NPL4, promoting oxidative stress, and inducing ferroptosis ( Furthermore, combination therapy with disulfiram and conventional chemotherapeutic agents (e.g., PARP inhibitors, sorafenib, doxorubicin) has demonstrated synergistic effects in vitro and in animal models, partially overcoming tumor resistance and improving therapeutic efficacy ( Through co-delivery via nanocarriers, precise release of disulfiram and metal ions can be achieved, enhancing drug stability and tumor targeting while reducing systemic toxicity ( 6 Conclusion and outlook As a major threat to mens health, urological cancers have shown an increasing incidence trend in recent years

Stomach lymph nodes can also become swollen if lymphoma cells accumulate there, potentially causing more pain and pressure

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