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Since many issues regarding the immune, both innate and adaptive, response remains unclear, they are subject to ongoing multi-omic investigations 1 , as well as comprehensive meta-analysis of global metabolomics datasets of COVID-19 2

Additionally, EGCG can modulate epigenetic machinery by inhibiting DNA methyltransferases and histone deacetylases (HDACs), reactivating silenced tumorsuppressor genes

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10.4161/auto.6.7.12754 Autophagy 50 FilomeniG.PiccirilloS.RotilioG.CirioloM

This crucial phase of the malady, in analogy with other viral infections and to a widely accepted pharmacological praxis, should be timely treated either with etiotropic drugs (which in COVID-19 case are still lacking) as well as with host-directed agents to manage/prevent the symptoms (Sestili and Stocchi, 2020)