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The functions of amylin are complementary to insulin and to GLP-1 : Slows gastric emptying , similarly to GLP-1, but more strongly Suppresses glucagon , helps control postprandial glycemia Induces satiety , via the area postrema in the brainstem Regulates weight balance , long-term effect In type 2 diabetes amylin secretion deteriorates in parallel with insulin secretion , as the disease progresses, the -cells lose the ability to produce both hormones at once

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It is evident that the presence of metal ions retards fiber formation with a significant increase of lag phase, reduces the elongation rate, but induces the formation of more fiber at the end of the process (Table 2)

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44,45 For morphology, the endothelial cells in the BBB are fastened by both tight junctions and adherens junctions, resulting in distinct lumenal and abluminal membrane compartments