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One should consider the primary phase lesion and hemorrhaging that results from mechanical damage during SCI as well as the secondary phase lesion that lasts several hours or even several months and is accompanied by edema, hemorrhage, inflammation, and cytotoxic edema [44,45,46,47] and may extend to the white matter area and lead to white matter degeneration and damage [48, 49]

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Phase 1 safety trials must determine maximum tolerated dose and identify adverse effects

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As the body's primary G-actin sequestering peptide, it maintains pools of monomeric actin available for rapid cytoskeletal reorganization, accelerating cell migration from distant sites to the wound