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A key regulator of mitochondrial biogenesis is peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PGC-1), which activates nuclear transcription factors NRF1 and NRF2, along with mitochondrial transcription factor A (TFAM)

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It is involved in the synthesis of amino acids, contributes to cell division, the build-up of maternal tissue during pregnancy and to reducing tiredness and fatigue