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In addition, Caveolin-1 (Cav-1), a 21-kDa integral plasma membrane protein is a well-known negative regulator of eNOS activity in vascular endothelial cells 1722

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Alcohol can interfere with the normal absorption of B12 in the gut The body's ability to absorb B12 from food can be reduced because alcohol can damage the lining of the stomach and intestines

Improvement will be gradual and may take several months, although some patients feel a difference quickly

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