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The 12mg weekly arm produced a 24.2% mean body weight reduction over 48 weeks, with 26% of participants achieving at least 30% total body weight loss a threshold previously unattained by any pharmacological intervention in a clinical trial setting

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MK-677 has shown its effectiveness in raising GH and IGF-1 levels, with evidence that these levels remain elevated for up to 24 hours after a single dose

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