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Viral replication and cell to cell transmission suppress ACE2 expression, which has an essential role in the renin angiotensin aldosterone system (RAAS), acting as a key counter-regulatory component

It was suggested that MRP1 inhibitors might be developed that could be useful in the treatment of inflammatory disorders, including those involving the airways such as asthma and chronic obstructive pulmonary disease (17, 23)

A detailed overview of the current approaches towards SC-based treatment of Parkinsons disease, including common strategies and challenges, can be seen in Fig