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History & Evolution Biosynthesis & dietary uptake Methylmalonic acid and the microbiome Methylmalonic acid and vitamin B12 deficiency Methylmalonic acid and neurology Methylmalonic acid and 5P medicine References History & Evolution 1963: First clinical description in pernicious anemia | 1967: Discovery of methylmalonic aciduria | 1968: Vitamin B12 responders in methylmalonyl-CoA deficiency | 1993: Methylmalonic acid (MMA) as biomarker for vitamin B12 deficiency Methylmalonic acid (MMA) was first linked to human disease in 1963, when researchers observed elevated urinary levels in patients with pernicious anemia (Barness et al

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