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Furthermore, in many of these studies, genes directly involved in glutathione synthesis such as GSH1 [33], gshF encoding bifunctional glutathione synthase [34], and PRO1 encoding -glutamyl kinase [35] are overexpressed

In the past three decades, however, diversity in clinical trials became a policy priority, advanced by federal agencies such as the Food and Drug Administration (FDA) Office of Womens Health and the Society for Womens Health Research (SWHR), and later by the FDA Office of Minority Health (OMH), established in 2010 (FDA, 2011)

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Because of this, the functions of MSM may span several cell types, which makes pinpointing its exact direct and indirect effects difficult