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An increase in the expression and activation of histone deacetylase 2 (HDAC2) inhibits MnSOD expression by reducing the acetylation levels at histone 3 lysine 9 (H3K9) and H3K27, thereby inducing oxidative stress and apoptosis in ECs under diabetic conditions [101]

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It has been reported that the upregulation of TNF and IL-13 in intestinal tissues of IBD can promote both leak and pore permeability pathways, as feedforward and positive feedback controls of cytokine-induced intestinal barrier loss and vice versa as a vicious cycle

Intracellular Oxidation-Reduction States in Vivo The microfluorometry of pyridine nucleotide gives a continuous measurement of the oxidation state

Yang J, Ylipaa A, Sun Y, Zheng H, Chen K, Nykter M, et al
