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(In the Supporting Information, Table S1 presents the chemical compounds and their function on affecting mPTP formation)

The mevalonate pathway (MEP) is a metabolic pathway that uses acetyl-coA as a raw material to synthesize isoprene pyrophosphate (IPP) and dimethylallyl pyrophosphate (DMAPP), which play an important role in regulating cell growth, differentiation, and proliferation

140,141 Findings from animal and human studies suggest resveratrol may improve metabolic parameters, male hormone levels, ovarian function, and fertility in PCOS