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Description
physical blockers give the most reliable protection
Inhibition of vitamin K epoxidase decreases the synthesis of these clotting factors, but the complex has a long half-life (about 14 hours), and it is this half-life that determines how long it takes for the concentration of clotting factors to reach a new steady state and for a drug effect to reflect the average warfarin plasma concentration
D.HanninkM
(New York, NY: Springer New York), 2354
Ultrapure water produced by a Milli-Q system (Sigma-Aldrich Canada, Oakville, ON, Canada) was used in all experiments
