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IGF-1 is the principal mediator of growth hormone (GH), it plays a crucial role in promoting cell growth and differentiation in childhood and continues to have an anabolic effect in adults

M.BuilA.AlmasyL.Ordoez-LlanosJ.et al (2005)

Body mass index (BMI) of 27 or greater with at least one weight-related health condition such as hypertension (high blood pressure), type 2 diabetes mellitus, hypercholesterolemia (high cholesterol), and sleep apnea

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