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10.1038/s41591-019-0568-2 Nat Med

When NOT to Use Modifier 25: Five Named Violations and What Payers Flag These five violations are the patterns OIG auditors, MAC reviewers, and commercial payer auditors flag most often when they review modifier 25

Future research directions may include the development of targeted drugs based on recently identified molecular targets such as AGEs, SHBG, and miRNAs, which show promising therapeutic potential

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For example, using 13 C-labeled 2-fluoro-2-deoxy-D-glucose (FDG) combined with nuclear magnetic resonance, a study found that glucose phosphorylation in nerve terminals significantly increases during acute neuronal activity (such as seizures), confirming the activity-dependent glucose uptake and glycolytic capacity of neurons