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The clinical onset and progression of metabolic and neurodegenerative disorders is closely tied to aging, dysfunction in telomere processing, and the processes of cellular senescence and oxidative stress ( Table 1 )

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The column used was an Agilent C18 column (Pursuit XRs C18, 100 2.0 mm, 5 m) with a guard column, maintained at 45 C in a column oven compartment