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This helps explain why one small molecule can have such wide-ranging effects

154 Although the sirtuin family proteins are reported to regulate histone acetylation in CD4 T cells, this is a largely unexplored aspect of the metabolic-epigenetic axis warranting further study

Priority research needs include large-scale randomized controlled trials to establish efficacy and safety, dose-ranging studies to optimize treatment protocols, long-term safety studies particularly regarding cancer risk, and comparative effectiveness research with established therapies

Consequently, H

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