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Circulation Cardiovascular quality and outcomes

doi: 10.1124/jpet.104.067660

Do not combine with semaglutide or tirzepatide

Using the free base can lead to non-uniform suspensions, inaccurate dosing, and lower-than-expected plasma concentrations, directly compromising the integrity of pharmacokinetic and pharmacodynamic studies that rely on the published clinical trial data established with the phosphate form