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Using SH-SY5Y cells exposed to high glucose concentrations to induce hyperglycemia, disruptions in glucose sensing leads to activation of the phosphorylated protein kinase B (pAkt)/GSK-3 signaling pathway, and increased expression of BACE and A42, an effect that can be reversed via pretreatment with melatonin [62]

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IDH mutations were first reported in GBM and were later found in other tumors, such as AML, cholangiocarcinoma, and chondrosarcoma (Parsons et al., 2008

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