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coli isolates obtained from beef

This was accompanied by upregulation of inducible nitric oxide synthase (iNOS), IL-1, and TNF-, and downregulation of arginase 1 (Arg-1), IL-10, and transforming growth factor-beta (TGF-)

These signaling pathways, enzymes, and transcription factors are essential in maintaining macrophage activation and M1 polarization by driving metabolic reprogramming (17)

Mitochondria play a crucial role in the production of energy in the form of ATP and are essential for oocyte maturation, fertilization, and early embryonic development [53]

An anti-proliferative and pro-apoptotic effect of iodine has been reported in preclinical studies on breast and gastric cancer cells (393), suggesting the importance of supplementation in iodine-poor areas