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2.3.4 Brain Approximately 5%-10% of reproductive-age women without PCOS worldwide experience depression and anxiety, and 40% of women with PCOS suffer from depression (116)

Apart from the obvious differentiation of satellite cells, which may account for many of the beneficial actions of exercise training, without excluding the classical fat burning, cardiovascular tonification, neuroendocrine system activation and chronic inflammation grade lowering

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538 p 81

proposed that we could regard the activation of NLRPs as an upstream step in the IL-1R and IL-18R signaling cascades due to their capacity to recruit MyD88 involving NF-B and thus directly linked intracellular pathogen recognition to signaling pathways shared with TLRs (42)