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K., Kuo, Y
B12 reduces pro-inflammatory cytokines and oxidative stress in nerve cells (Yang et al., 2021)
Experimental models demonstrate that FOXO proteins mediate the inhibitory effects of insulin/IGF on target genes and are essential for maintaining metabolic homeostasis
This correlation does not tell us whether the symptom improvement was driven by weight loss, direct anti-inflammatory effects, or both, but it confirms that the metabolic improvements tracked alongside the symptom improvements
In this case, the binding was measured towards a recombinant truncated and soluble form of the receptor
